PREPARATION, CHARACTERIZATION, AND CYTOTOXIC EVALUATION OF DOCETAXEL-LOADED POLYMERIC NANOPARTICLES USING NOVEL POLYMER SOLUPLUS® AS SURFACTANT

DOI: https://doie.org/10.0126/Jbse.2025601255

Sapana Shyamal Chaudhari , Dr. Chainesh Shah, Dr. Shahzad Ahmed A. R

Keywords:

Docetaxel, Nanoparticle, Anticancer, Soluplus®, Surfactant, Chemotherapy

Abstract:

For better targeted delivery of docetaxel, the goal of this work was to create folate surface-engineered pegylated PLGA nanoparticles using Soluplus® as the only surfactant. The nanoparticles were created using a modified nanoprecipitation technique with Soluplus® as the surfactant. A variety of formulations' drug loading, zeta potential, particle size, polydispersity index, and entrapment efficiency were created and evaluated. Scanning electron microscopy was used to analyse and assess the nanoparticles' morphology. To find out if nanoparticles are more cytotoxic than free medicines, the MTT test was employed. As the nanoparticles were successfully fabricated, it was demonstrated that they outperformed free medicines in terms of cytotoxicity.

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