EVALUATION OF POTENTIAL HYPOGLYCEMIC ACTIVITY OF PRONIOSOMAL GEL CONTAINING GLIPIZIDE

DOI: https://doie.org/10.0219/Jbse.2025553479

Ankit Kumar, Priyanka Singh, Mohit Panwar, Manu Sharma, Himanshu Kumar, Namita Sharma

Keywords:

Glipizide, Proniosomes, Entrapment Efficiency, Controlled release, Hypoglycemic activity etc.

Abstract:

For the purpose of transdermal delivery of the hypoglycemic agent Glipizide, novel vesicular drug carrier system proniosomes are being developed, evaluated, and stability studies are being conducted. Proniosomes were investigated as a new drug delivery technique for enhancing Glipizide permeation through the skin. A glipizide proniosomal gel was made using a coacervation-phase separation technique, a non-ionic surfactant (span 60), cholesterol, and lecithin, along with various medication combinations.  Physical appearance, pH, vesicle size, entrapment efficiency, drug content uniformity, surface morphology, zeta potential analysis, in-vitro drug release, kinetic model, skin irritant test, hypoglycemic action, and stability tests were all used to evaluate proniosome formulations. The AF4 formulation has a higher drug content and entrapment efficiency than all other formulations combined.  In-vitro release after 24 hrs from AF4 formulation showing better control on release compare to other formulations.  Proniosomal gel formulation AF4 was found to be non-irritant, superior stability, and a greater hypoglycemic effect than oral formulations.  Because it reduces blood, glucose levels in a regulated manner for up to 24 hours. As a result, the Proniosomal drug delivery system was a proved to better option for controlled drug release via topical medication delivery.

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