ANTIOXIDANT, HEPATOPROTECTIVE AND ANTICANCER ACTIVITY OF GYNURA PROCUMBENS ROOT EXTRACT: AN IN VITRO MECHANISTIC PHARMACOLOGICAL APPRAISAL

DOI: https://doie.org/10.0126/Jbse.2025686221

Priyanka Sukdev Pagare , Dr. Chainesh Shah , Dr. Shahzad Ahmed A. R

Keywords:

Antiradical, Antioxidant, Hepatoprotective, Gynura procumbens, ABTS radical, Anticancer

Abstract:

This study looked into the potential medical benefits of GPME-R, a herbal methanol extract made from the roots of Gynura procumbens. To ascertain GPME-R's therapeutic potential, we carried out a number of in vitro tests, paying special attention to its capacity to combat oxidative stress and maintain & protect liver function. The cytotoxicity assessment of the extract was also used to assess its anticancer potential. The ABTS radical scavenging assay and the hydroxyl radical scavenging activity were evaluated. The outcomes were extremely encouraging, demonstrating GPME-R's potent capacity to combat dangerous free radicals, which are recognized to be hallmark factor in oxidative stress. Additionally, we employed a model involving HepG2 cells that were exposed to carbon tetrachloride, a typical chemical hepatotoxin used to research liver injury in the lab, to investigate how GPME-R could protect liver cells. According to the findings, GPME-R significantly shielded these liver cells from the damaging effects of the chemical toxin CCl4. Additionally, the extract GPME-R showed a negligible cytotoxic impact. Overall, the results of our investigation demonstrated the effectiveness of GPME-R as a strong hepatoprotective and antioxidant. More research is needed, though, as the anticancer potential was determined to be limited and unclear. This implied that GPME-R might be a useful natural remedy for controlling oxidative stress and enhancing & protecting liver function.

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